From the South China University of Technology, it was learned that Wang Xiaoning, the school’s School of Biological Science and Engineering, has made breakthroughs in the research on the molecular mechanisms of the pathogenic type II Streptococcus suis co-ordinated and participated in. The paper was selected as a research highlight in Nature China.
According to the introduction, the two-component signal transduction system of S. suis, a two-component signal transduction system that is coordinated by and involved in the collaboration between Wang Xiaoning and the School of Biological Sciences and Engineering, South China University of Technology, is essential for full virulence of highly Invasive Streptococcus suis serotype 2 was published in the high-level academic journal PLoS ONE and published by Nature China as a research highlight, marking the institute A new step has been made in the study of microbiology science.
Type II swine streptococcosis is a major infectious zoonotic disease, caused mainly by infection with type II swine streptococci. For the first time in 1998, the epidemic broke out in Jiangsu, and in 2005 a second outbreak occurred in Sichuan, causing dozens of sudden deaths. Due to the dangerous course, great social panic and economic losses were caused.
It is understood that Professor Tang Jiaqi of the Nanjing Military Region CDC is the first Chinese scientist to isolate and identify the pathogen of swine streptococcus, and has a long-term cooperation experience with Professor Wang Xiaoning. In 2004, after Professor Wang Xiaoning came to China, he combined discipline development trends, further strengthened the cooperation with Prof. Tang, and coordinated and promoted the cooperation research of the project, forming the Huada Genome Institute, the Institute of Microbiology, Chinese Academy of Sciences, and the Academy of Military Medical Sciences. The research team formed by other domestic top-notch institutions, such as the Military Medical University, responded quickly after the epidemic in Sichuan and carried out a series of high-level studies, which have been successively in the "Public Science Library and Medicine" (PLoS Medicine, IF 13.9). ) and PLoS ONE published many research papers in high-level magazines.
In addition to the first international report of the toxic shock syndrome caused by Streptococcus suis, it also took the lead in completing the whole-genome sequence analysis of Streptococcus suis type II in China, and found a brand-new virus island-like plasmid gene. Based on the above work, this study further discovered and confirmed a binary regulatory gene closely related to the pathogenesis of the pathogen. The results were selected by Nature China as "Infectious Diseases: The Cause of Death", further establishing the leading position of scientists in this field in the world.
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